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Substance Toxicology & Benchmarks

Contaminant Directory

Comprehensive reference on chemical analytes, health benchmarks, statutory limits, and certified reduction methods.

pfasCAS: 335-67-1

PFOA

Perfluorooctanoic acid

Federal Standard:4 ng/L (MCL); MCLG of 0
Health Benchmark:4 ng/L (0.004 µg/L) enforceable federal limit (MCL), effective 2029

PFOA is a per- and polyfluoroalkyl substance (PFAS) — a synthetic "forever chemical" that resists breaking down in water and the body.

Reverse osmosisActivated carbon (GAC)Anion exchange
pfasCAS: 1763-23-1

PFOS

Perfluorooctanesulfonic acid

Federal Standard:4 ng/L (MCL); MCLG of 0
Health Benchmark:4 ng/L (0.004 µg/L) enforceable federal limit (MCL), effective 2029

PFOS is a PFAS "forever chemical" closely related to PFOA, historically used in stain- and water-repellent products and firefighting foam.

Reverse osmosisActivated carbon (GAC)Anion exchange
pfasCAS: 355-46-4

PFHxS

Perfluorohexanesulfonic acid

Federal Standard:10 ng/L (MCL)
Health Benchmark:10 ng/L individual MCL (and a hazard-index limit combined with other PFAS)

PFHxS is a shorter-chain PFAS "forever chemical" regulated under the EPA PFAS rule as part of a hazard index alongside other PFAS.

Reverse osmosisActivated carbon (GAC)Anion exchange
metalsCAS: 7439-92-1

Lead

Lead (Pb)

Federal Standard:Action level 15 µg/L (90th percentile)
Health Benchmark:15 µg/L action level (90th percentile); MCLG of 0

Lead is a toxic metal that usually enters drinking water from corrosion of lead service lines, solder, and household plumbing rather than from the source water.

Reverse osmosisNSF/ANSI 53 lead-certified filtersReplacing lead service lines
disinfection byproducts

Total trihalomethanes (TTHM)

Trihalomethanes

Federal Standard:80 µg/L (MCL)
Health Benchmark:80 µg/L federal limit (MCL)

TTHMs are disinfection by-products that form when chlorine reacts with natural organic matter in water. They are the trade-off of effective disinfection.

Activated carbonReverse osmosis
disinfection byproducts

Haloacetic acids (HAA5)

Haloacetic acids (five)

Federal Standard:60 µg/L (MCL)
Health Benchmark:60 µg/L federal limit (MCL)

HAA5 is a group of five haloacetic acids — disinfection by-products that, like TTHMs, form when chlorine reacts with organic matter.

Activated carbonReverse osmosis
characteristics

Hard water

Calcium and magnesium hardness

Federal Standard:Reference information not connected in this preview
Health Benchmark:

Hardness is dissolved calcium and magnesium picked up from rock and soil. It is an aesthetic and plumbing consideration, not a health-based contaminant.

Ion-exchange water softenerSalt-free conditionerReverse osmosis (point-of-use)
metalsCAS: 7440-38-2

Arsenic

Arsenic (As)

Federal Standard:10 µg/L (MCL)
Health Benchmark:10 µg/L federal limit (MCL); MCLG of 0

Arsenic is a naturally occurring semi-metal that dissolves into groundwater from rock and soil, and can also enter water from mining and legacy agricultural chemicals.

Reverse osmosisAnion exchangeActivated alumina / adsorptive media
inorganicsCAS: 14797-55-8

Nitrate

Nitrate (as N)

Federal Standard:10 mg/L as nitrogen (MCL)
Health Benchmark:10 mg/L (as N) federal limit (MCL)

Nitrate is a nitrogen compound that enters water mainly from fertilizer, animal waste, and septic systems — one of the most common contaminants in agricultural areas.

Reverse osmosisAnion exchangeDistillation
disinfection byproducts

Chlorine

Free chlorine / chloramine residual

Federal Standard:MRDL 4 mg/L (as Cl2)
Health Benchmark:4 mg/L maximum residual disinfectant level (MRDL)

Chlorine is the disinfectant most utilities add to control bacteria and viruses as water travels through the pipes. A residual at your tap is a sign disinfection is working; some systems use chloramine for a longer-lasting residual.

Activated carbonCatalytic carbon (for chloramine)
metalsCAS: 18540-29-9

Chromium-6

Hexavalent chromium (Cr-VI)

Federal Standard:No dedicated federal Cr-6 limit; total chromium 100 µg/L. California sets a Cr-6 MCL of 10 µg/L.
Health Benchmark:No separate federal MCL; total chromium MCL is 100 µg/L

Hexavalent chromium (chromium-6) is a form of chromium from industrial processes and some natural deposits — the contaminant made famous by the Erin Brockovich case.

Reverse osmosisAnion exchangeReduction / filtration systems
metalsCAS: 7440-50-8

Copper

Copper (Cu)

Federal Standard:Action level 1.3 mg/L (90th percentile)
Health Benchmark:1.3 mg/L action level (90th percentile); MCLG of 1.3 mg/L

Copper is a metal that usually enters drinking water from the corrosion of household copper pipes and brass fixtures rather than from the source water. Small amounts are an essential nutrient; the concern is elevated levels.

Reverse osmosisCorrosion-control / pH adjustmentFlushing standing water before use
inorganicsCAS: 16984-48-8

Fluoride

Fluoride ion (F−)

Federal Standard:4.0 mg/L (MCL)
Health Benchmark:4.0 mg/L enforceable federal limit (MCL); MCLG of 4.0 mg/L

Fluoride occurs naturally in groundwater and is also added by many utilities at low levels to reduce tooth decay. It is regulated because very high natural levels can affect teeth and bones.

Reverse osmosisActivated alumina / adsorptive mediaDistillation
inorganicsCAS: 14797-65-0

Nitrite

Nitrite (as N)

Federal Standard:1 mg/L as nitrogen (MCL)
Health Benchmark:1 mg/L (as N) federal limit (MCL); MCLG of 1 mg/L

Nitrite is a nitrogen compound closely related to nitrate, formed as nitrate is converted in the environment or in treatment. It shares nitrate’s sources but is regulated at a lower level.

Reverse osmosisAnion exchangeDistillation
metalsCAS: 7440-39-3

Barium

Barium (Ba)

Federal Standard:2 mg/L (MCL)
Health Benchmark:2 mg/L federal limit (MCL); MCLG of 2 mg/L

Barium is a metal that enters drinking water mostly through the natural erosion of mineral deposits, and sometimes from industrial discharge or oil-and-gas activity.

Reverse osmosisIon exchange (softening)Electrodialysis
metalsCAS: 7782-49-2

Selenium

Selenium (Se)

Federal Standard:0.05 mg/L / 50 µg/L (MCL)
Health Benchmark:0.05 mg/L (50 µg/L) federal limit (MCL); MCLG of 0.05 mg/L

Selenium is a trace element that is an essential nutrient in tiny amounts but is regulated in drinking water because higher levels from natural deposits or runoff can be harmful.

Reverse osmosisAnion exchangeActivated alumina
metalsCAS: 7440-43-9

Cadmium

Cadmium (Cd)

Federal Standard:0.005 mg/L / 5 µg/L (MCL)
Health Benchmark:5 µg/L (0.005 mg/L) federal limit (MCL); MCLG of 5 µg/L

Cadmium is a toxic metal that can enter water from the corrosion of galvanized pipes and from industrial discharge, mining, and runoff.

Reverse osmosisIon exchangeActivated carbon (some configurations)
metalsCAS: 7439-97-6

Mercury

Inorganic mercury (Hg)

Federal Standard:0.002 mg/L / 2 µg/L (MCL)
Health Benchmark:2 µg/L (0.002 mg/L) federal limit (MCL); MCLG of 2 µg/L

Inorganic mercury is a toxic metal that reaches water from natural deposits, industrial discharge, and runoff. The drinking-water rule addresses inorganic mercury, distinct from the methylmercury that builds up in fish.

Reverse osmosisActivated carbon (GAC)Coagulation / filtration
metalsCAS: 7440-36-0

Antimony

Antimony (Sb)

Federal Standard:0.006 mg/L / 6 µg/L (MCL)
Health Benchmark:6 µg/L (0.006 mg/L) federal limit (MCL); MCLG of 6 µg/L

Antimony is a metal that can enter drinking water from natural deposits and from discharge related to petroleum refineries, fire retardants, ceramics, and electronics.

Reverse osmosisCoagulation / filtration
radionuclidesCAS: 7440-61-1

Uranium

Uranium (U)

Federal Standard:30 µg/L (MCL)
Health Benchmark:30 µg/L federal limit (MCL); MCLG of 0

Uranium is a naturally occurring radioactive metal that dissolves into groundwater from uranium-bearing rock. It poses both a chemical (kidney) risk and a radiological one.

Reverse osmosisAnion exchangeCoagulation / filtration
radionuclides

Radium (226 + 228)

Combined radium-226 and radium-228

Federal Standard:5 pCi/L combined radium-226 + 228 (MCL)
Health Benchmark:5 pCi/L combined federal limit (MCL); MCLG of 0

Radium is a naturally occurring radioactive element that dissolves into groundwater from rock and soil. It is regulated as the combined activity of radium-226 and radium-228.

Reverse osmosisIon exchange (softening)Activated alumina
radionuclides

Gross alpha particles

Gross alpha particle activity

Federal Standard:15 pCi/L, excluding radon and uranium (MCL)
Health Benchmark:15 pCi/L federal limit (MCL); MCLG of 0

Gross alpha is a combined measure of alpha-particle radioactivity in water — a screening figure for naturally occurring radionuclides such as radium and polonium (excluding radon and uranium).

Reverse osmosisIon exchangeActivated alumina
vocsCAS: 71-43-2

Benzene

Benzene

Federal Standard:0.005 mg/L / 5 µg/L (MCL)
Health Benchmark:5 µg/L (0.005 mg/L) federal limit (MCL); MCLG of 0

Benzene is a volatile organic compound (VOC) found in gasoline and industrial solvents. It can reach groundwater from fuel leaks, industrial discharge, and landfills.

Activated carbon (GAC)Packed-tower aeration (air stripping)Reverse osmosis
vocsCAS: 79-01-6

Trichloroethylene (TCE)

Trichloroethylene

Federal Standard:0.005 mg/L / 5 µg/L (MCL)
Health Benchmark:5 µg/L (0.005 mg/L) federal limit (MCL); MCLG of 0

Trichloroethylene (TCE) is a volatile organic compound used as an industrial degreaser and solvent. It is a common groundwater contaminant near industrial and defense sites.

Activated carbon (GAC)Packed-tower aeration (air stripping)Reverse osmosis
vocsCAS: 127-18-4

Tetrachloroethylene (PCE)

Tetrachloroethylene (perchloroethylene)

Federal Standard:0.005 mg/L / 5 µg/L (MCL)
Health Benchmark:5 µg/L (0.005 mg/L) federal limit (MCL); MCLG of 0

Tetrachloroethylene (PCE, "perc") is a volatile organic compound used in dry cleaning and metal degreasing. It reaches groundwater from dry-cleaner sites and industrial discharge.

Activated carbon (GAC)Packed-tower aeration (air stripping)Reverse osmosis
vocsCAS: 75-01-4

Vinyl chloride

Vinyl chloride (chloroethene)

Federal Standard:0.002 mg/L / 2 µg/L (MCL)
Health Benchmark:2 µg/L (0.002 mg/L) federal limit (MCL); MCLG of 0

Vinyl chloride is a volatile organic compound used to make PVC plastic. In water it often appears as a breakdown product of other solvents like TCE and PCE, and can leach from old PVC piping.

Packed-tower aeration (air stripping)Activated carbon (GAC)Reverse osmosis
pfasCAS: 62037-80-3

GenX (HFPO-DA)

Hexafluoropropylene oxide dimer acid (HFPO-DA)

Federal Standard:10 ng/L (MCL); MCLG of 10 ng/L
Health Benchmark:10 ng/L individual MCL; also limited via a combined PFAS hazard index

GenX (HFPO-DA) is a newer PFAS "forever chemical" introduced as a replacement for PFOA. It is now federally regulated both on its own and as part of a PFAS hazard index.

Reverse osmosisActivated carbon (GAC)Anion exchange
pfasCAS: 375-95-1

PFNA

Perfluorononanoic acid

Federal Standard:10 ng/L (MCL); MCLG of 10 ng/L
Health Benchmark:10 ng/L individual MCL; also limited via a combined PFAS hazard index

PFNA is a longer-chain PFAS "forever chemical" regulated under the EPA PFAS rule both individually and as part of a combined hazard index with other PFAS.

Reverse osmosisActivated carbon (GAC)Anion exchange
characteristics

Microplastics

Microplastic particles (< 5 mm)

Federal Standard:None — not federally regulated in drinking water
Health Benchmark:No federal drinking-water limit (unregulated as of 2026)

Microplastics are plastic fragments smaller than 5 millimetres — down to microscopic nanoplastics — that shed from packaging, textiles, tyres and the breakdown of larger plastic waste. They are an emerging contaminant: increasingly detected in tap and bottled water, but not yet federally regulated in drinking water.

Reverse osmosisNanofiltrationFine activated-carbon block filtration

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